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KMID : 1161320220370010002
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Journal of Animal Reproduciton and Biotechnology
2022 Volume.37 No. 1 p.2 ~ p.12
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The theranostic roles of extracellular vesicles in pregnancy disorders
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Saadeldin Islam M.
Tanga Bereket Molla
Bang Seong-Gyu
Fang Xun
Yoon Ki-Young
Lee Sang-Hoon
Cho Jong-Ki
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Abstract
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Extracellular vesicles (EVs) are nanovesicles that carry bioactive cargoes of proteins, lipids, mRNAs, and miRNAs between living cells. Their role in cellular communication has gained the attention of several research reports globally in the last decade. EVs are critically involved in sperm functions, oocyte functions, fertilization, embryonic development, and pregnancy. The review summarizes the state-of-the-art of EVs research in the diagnostic and therapeutic (theranostic) potentials of the EVs during the pregnancy that might provide a solution for gestational disturbances such as implantation failure, maternal health problems, gestational diabetes, and preeclampsia. EVs can be found in all biological fluids of the fetus and the mother and would provide a non-invasive and excellent tool for diagnostic purposes. Moreover, we provide the current efforts in manufacturing and designing targeted therapeutics using synthetic and semi-synthetic nanovesicles mimicking the natural EVs for efficient drug delivery during pregnancy.
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KEYWORD
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diagnosis, extracellular vesicles, placenta, pregnancy, therapy
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